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Some animals presenting with heart failure for the 1st time may have severe clinical signs requiring aggressive therapy (eg, with additional afterload reducers or temporary ventilatory assistance) that more typically would be reserved for those with refractory disease (see Stage D)

They should never be utilized in research models involving active cancerous tumors, as angiogenesis can theoretically accelerate tumor growth by supplying blood to the malignant tissue

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The practical implication is that secretagogues work within the body's own feedback loops

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